Home About us Editorial board Browse Articles Submit article Instructions Subscribe Contacts Login 
  • Users Online: 92
  • Home
  • Print this page
  • Email this page
CASE REPORT
Year : 2015  |  Volume : 6  |  Issue : 1  |  Page : 3

Exceptional association between Klinefelter syndrome and growth hormone deficiency


1 Department of Endocrinology and Metabolism, University Hospital Hassan II, Fez, Morocco
2 Department of Biophysics and Clinical MRI Methods, Faculty of Medicine and Pharmacy, University of Fez, BP. 1893, Km 2.200, Sidi Hrazem Road, Fez - 30000, Morocco
3 Department of Endocrinology and Metabolism, University Hospital Hassan II; Medical Center of Biomedical and Translational Research; Department of Pharmacology, Central Laboratory for Medical Analyses, University of Fez, Fez, Morocco

Correspondence Address:
Sad Boujraf
Department of Biophysics and Clinical MRI Methods, Faculty of Medicine and Pharmacy, University of Fez, BP. 1893, Km 2.200, Sidi Hrazem Road, Fez - 30000
Morocco
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2041-9414.165531

Rights and Permissions

Klinefelter syndrome (KS) is characterized in adults by the combination of a tall stature, small testes, gynecomastia, and azoospermia. This case is described in a North African population of the Mediterranean region of North Africa. We report the case of a male 16 years old, of Arab ethnic origin, and diagnosed with this syndrome, who had a small height in relation to a growth hormone (GH) deficiency and a history of absence seizures (generalized myoclonic epilepsy). The patient's size was <−2.8 standard deviation (SD) with weight <−3 SD. GH deficiency was isolated and confirmed by two dynamic tests (insulin - hypoglycemia tolerance test and clonidine) with normal hypothalamic magnetic resonance imaging (MRI). GH supplementation using recombinant GH was advocated, while gonadotropin treatment was deferred. Small size in children or adolescents should not eliminate the diagnosis of Klinefelter syndrome - on the contrary, the presence of any associated sign (brain maturation, delay in puberty, aggressiveness) should encourage one to request a karyotype for the diagnosis and appropriate care of any case of KS that can be associated with GH deficiency, or which is in a variant form (isochromosome Xq, 49,XXXXY).


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1990    
    Printed186    
    Emailed0    
    PDF Downloaded94    
    Comments [Add]    
    Cited by others 1    

Recommend this journal