RT - Journal
TY - JOUR
A1 - Kang, Chang-Mo
A1 - Yun, Hyun
A1 - Kim, Hanna
A1 - Kim, Cha
T1 - Strong correlation among three biodosimetry techniques following exposures to ionizing radiation
YR - 2016/1/1
JF - Genome Integrity
JO - Genome Integr
SP - 11
OP - 11
VO - 7
IS - 1
UL - https://www.genome-integrity.org/article.asp?issn=2041-9414;year=2016;volume=7;issue=1;spage=11;epage=11;aulast=Kang;t=5
DO - 10.4103/2041-9414.197168
N2 - Three in vitro dose calibration curves for biodosimetry such as dicentric chromosome assay, fluorescence in situ hybridization (FISH) assay for translocation, and micronuclei (MNs) in binucleated cell assay were established after exposure to ionizing radiation. Peripheral blood lymphocyte samples obtained from healthy donors were irradiated with 60Co source at a dose rate of 0.5 Gy/min to doses of 0.1–6 Gy. The results from three in vitro dose calibration curves for biodosimetry were analyzed to understand the relationship among biodosimetry assay techniques. Our comparison demonstrates that there is a very strong positive correlation among the dicentric assay, FISH, and MNs analysis, and these three biodosimetry assays strongly support the in vitro dose reconstruction and the emergency preparedness of public or occupational radiation overexposure.
ER -