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ORIGINAL ARTICLE
Year : 2021  |  Volume : 12  |  Issue : 1  |  Page : 1-7

Conventional risk factors, telomere length, and ischemic heart disease: Insights into the mediation analysis


1 Intern, KAHER, Belagavi, Karnataka, India
2 Department of General Medicine, KAHER, Belagavi, Karnataka, India
3 Department of Radiology, M.V.J Medical College, Belagavi, Karnataka, India
4 Department of Medicine, Jawaharlal Nehru Medical College, KAHER, Belagavi, Karnataka, India
5 Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA
6 Department of Cardiology, KAHER, Belagavi, Karnataka, India
7 Research Officer, Maratha Mandal's N.G.H Institute of Dental Sciences & Research Centre, Belagavi, Karnataka, India
8 Department of Cardiology, Mount Sinai St. Luke's and West Hospitals, New York, United States
9 Department of Medicine, University of California, Davis, United States
10 Department of Cardiology, Jaipur National University Institute of Medical Sciences and Research Center, Jaipur, Rajasthan, India

Correspondence Address:
Madhav Prabhu
Associate Professor, Department of General Medicine, KAHER, Belagavi - 590 003, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/genint.genint_1_21

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Telomere length is regarded as a potential biomarker of biological ageing and is associated with various age-related diseases, such as ischemic heart disease (IHD), myocardial infarction, peripheral vascular disease, and cancer. As there is a paucity of study that deals with this influence, this study aimed to assess how the cardiovascular risk factors influence the risk of IHD by performing mediation analysis. A total of 407 males were included in the study. IHD was diagnosed through echocardiography and coronary angiography by determining the number of coronary vessels involved. Demographic data, clinical history, and laboratory investigations such as random blood sugar (RBS), fasting lipid profile, serum creatinine, and serum urea levels of all the subjects were measured and recorded. Serum uric acid and blood urea nitrogen (BUN) levels were significantly higher in IHD subjects compared to non-IHD subjects (P < 0.05). Body mass index (BMI), glycosylated hemoglobin (HbA1c), RBS, serum uric acid, serum creatinine, BUN, total cholesterol, triglycerides, and telomere length significantly differed between subjects with and without IHD (P < 0.05). Further, telomere length (P < 0.001), BMI (P < 0.001), and total cholesterol level (P < 0.001) were risk factors that significantly affected the incidence of IHD, as proved by logistic regression. It indicates that shorter telomeres contribute to increased risk of IHD, influenced by BMI, HbA1c, BUN, total cholesterol levels, and RBS (P < 0.001). The study established a link between telomere shortening, conventional risk factors, and IHD; moreover, the study takes care in the role of mediation analysis which is a novel idea as little is done in this area of biostatistics with telomere length. Overall, this further establishes that telomeres length might serve as the promising biomarkers in predicting the risk of IHD.


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