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  Indian J Med Microbiol
 

Figure 1: Genome equivalent frequencies of chromosomal aberrations in 1000 cells (CA GE) estimated for the whole genome induced by 1.5 Gy of γR on human peripheral lymphocytes, recovered in the presence or absence of valproic acid during 48 h. SCA: Reciprocal and nonreciprocal translocations and UCA: Dicentrics, rings, and fragments were detected on whole chromosomes probes-fluorescent in situ hybridization of HSA 2, 4, and 12. Genome equivalent CA frequencies were estimated applying the Lucas formula from the observation of exchanges between painted chromosomes and unpainted chromosomes. (a) Frequency of total CA, SCA and UCA induced by γR and posttreated with 0.35 mM valproic acid; and (b) frequency of total CA, SCA and UCA induced by γR and posttreated with 0.70 mM of valproic acid. Frequency of CA in unirradiated blood cultures in the presence or absence of different doses of valproic acid is also shown. SCA: Stable chromosomal aberrations, UCA: Unstable chromosomal aberrations, γR: γ-rays

Figure 1: Genome equivalent frequencies of chromosomal aberrations in 1000 cells (CA GE) estimated for the whole genome induced by 1.5 Gy of γR on human peripheral lymphocytes, recovered in the presence or absence of valproic acid during 48 h. SCA: Reciprocal and nonreciprocal translocations and UCA: Dicentrics, rings, and fragments were detected on whole chromosomes probes-fluorescent in situ hybridization of HSA 2, 4, and 12. Genome equivalent CA frequencies were estimated applying the Lucas formula from the observation of exchanges between painted chromosomes and unpainted chromosomes. (a) Frequency of total CA, SCA and UCA induced by γR and posttreated with 0.35 mM valproic acid; and (b) frequency of total CA, SCA and UCA induced by γR and posttreated with 0.70 mM of valproic acid. Frequency of CA in unirradiated blood cultures in the presence or absence of different doses of valproic acid is also shown. SCA: Stable chromosomal aberrations, UCA: Unstable chromosomal aberrations, γR: γ-rays