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  Indian J Med Microbiol
 

Figure 4: Gene expression profiling in human lymphocytes following radiation exposure. (a) Principal component analysis of transcriptomic profile of human peripheral blood lymphocytes following exposure to gamma rays. Comparison was made between donors, doses, and data points. Three-dimensional principal component analysis of expression profiles from five samples revealed a striking pattern of clustering based on the postirradiation time. This implies that postirradiation time may be the most influential factor on gene expression changes. (b) Pathway and gene network of radiation-induced changes. The gene network was constructed using Pathway Studio (Ariadne Genomics MD, USA) on the basis of biological function of the differentially expressed genes by microarrays and the knowledge obtained in the literature. Red color denotes upregulated genes. Blue lines indicate direct regulation between genes based on literature evidence

Figure 4: Gene expression profiling in human lymphocytes following radiation exposure. (a) Principal component analysis of transcriptomic profile of human peripheral blood lymphocytes following exposure to gamma rays. Comparison was made between donors, doses, and data points. Three-dimensional principal component analysis of expression profiles from five samples revealed a striking pattern of clustering based on the postirradiation time. This implies that postirradiation time may be the most influential factor on gene expression changes. (b) Pathway and gene network of radiation-induced changes. The gene network was constructed using Pathway Studio (Ariadne Genomics MD, USA) on the basis of biological function of the differentially expressed genes by microarrays and the knowledge obtained in the literature. Red color denotes upregulated genes. Blue lines indicate direct regulation between genes based on literature evidence